Over the last decade, studies of natural hazards in Sumatra have focused primarily on great earthquakes and associated tsunamis produced by rupture of the Sunda megathrust. However, the Sumatran Fault and the active volcanic arc present proximal hazards to populations on mainland Sumatra. At present, there is little reliable information on the maximum magnitudes and recurrence intervals of Sumatran Fault earthquakes, or the frequency of paroxysmal caldera-forming (VEI 7–8) eruptions. Here, we present new radiocarbon dates of paleosols buried under the voluminous Ranau Tuff that constrain the large caldera-forming eruption to around 33,830–33,450 calender year BP (95% probability). We use the lateral displacement of river channels incised into the Ranau Tuff to constrain the long-term slip rate of two segments of the Sumatran Fault. South of Ranau Lake, the Kumering segment preserves isochronous right-lateral channel offsets of approximately 350 ± 50 m, yielding a minimum slip rate of 10.4 ± 1.5 mm/year for the primary active fault trace. South of Suoh pull-apart depression, the West Semangko segment offsets the Semangko River by 230 ± 60 m, yielding an inferred slip rate of 6.8 ± 1.8 mm/year. Compared with previous studies, these results indicate more recent high-volume volcanism in South Sumatra and increased seismic potency of the southernmost segments of the Sumatran Fault Zone.